Mối quan hệ giữa vitamin B12 thấp với lượng leptin cao hơn trong mô mỡ, mô nhau thai và dây rốn của người mẹ

Nhóm tác giả: Antonysunil Adaikalakoteswari, Manu Vatish, Ilona Goljan và Ponnusamy Saravanan.
Tạp chí : Society for Endocrinology British Endocrine Societies, Anh quốc.

Xuất bản: ngày 7/11/2016-9/11/2016.

Bối cảnh: Bằng chứng cho thấy sự thiếu hụt vitamin B12 của người mẹ trong các giai đoạn phát triển ảnh hưởng đến tình trạng trao đổi chất và mức độ hội chứng chuyển hóa của con cái sang tuổi trưởng thành. Vitamin B12 là cần thiết cho quá trình tổng hợp methionine, là tiền chất của S-adenosyl-methionine, một nguồn cung cấp methyl chính cho quá trình methyl hóa DNA. Vì vậy, thiếu vitamin B12 có thể gây ra thay đổi methyl hóa, được cho là làm thay đổi biểu hiện gen của các yếu tố điều tiết và có thể dẫn đến các kiểu hình chuyển hóa bất lợi. Nghiên cứu gần đây của chúng tôi cho thấy rằng vitamin B12 của người mẹ thấp có liên quan đến tình trạng lipid máu bất lợi và chỉ số BMI cao hơn, điều này cho thấy manh mối để khám phá ra mối liên hệ giữa dấu hiệu béo phì, leptin và vitamin B12. Chúng tôi đưa ra giả thuyết rằng B12 của mẹ có thể điều chỉnh nồng độ leptin trong tử cung. Do đó chúng tôi đã nghiên cứu xem mức độ liên quan giữa B12 của người mẹ với leptin trong mô mỡ, mô nhau thai và máu cuống rốn của người mẹ.

Phương pháp: Các mẫu máu tĩnh mạch và tĩnh mạch của người mẹ kết hợp (n = 91), mô mỡ (n = 42) và mô nhau thai (n = 83) được thu thập khi sinh. Vitamin B12 huyết thanh được xác định bằng xét nghiệm miễn dịch điện hóa học. Nồng độ leptin được đo bằng ELISA. ĐỂ đánh giá cơ chế cơ bản, dòng tế bào tiền chất adipocyte của con người (Chub-S7) được phân biệt ởcác mức độ B12 khác nhau (1) Kiểm soát: (B12-500 nM); (2) B12 thấp (0,15 nM); (3) Chất ức chế + methyl hóa (AZ): (B12-500 nM + 5-Aza-dC-200 nM).

Kết quả: Thiếu B12 (<150 pmol/l) là phổ biến (mẹ – 40%; trẻ sơ sinh-29%). Trong phân tích hồi quy, điều chỉnh cho những người có khả năng gây nhiễu, B12 mẹ độc lập liên quan đến leptin sơ sinh (B = -0,662; P = 0,002; R2 = 12,7%). Biểu hiện gen leptin cao hơn ở mô mỡ và mô nhau thai từ các bà mẹ có B12 thấp. Leptin gen cao hơn trong tế bào mỡ (Chubs-S7) nuôi cấy với B12 thấp (0,15 nM) và được điều trị bằng B12 bình thường (500 nM) với sự có mặt của chất ức chế methyl hóa (5-Aza-dC).

Kết luận: Nghiên cứu của chúng tôi nhấn mạnh rằng người mẹ có lượng B12 thấp có nồng độ leptin cao hơn trong máu, mô mỡ của người mẹ và mô nhau thai, cho thấy gen leptin có thể là cơ chế của chương trình bất lợi hoặc trong mô nhau thai hoặc mô mỡ của người mẹ.

NHC Healthcare (Tổng hợp từ Tạp chí Society for Endocrinology British Endocrine Societies, Anh quốc)

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